abstract：:Multiple sclerosis (MS) is a chronic autoimmune and degenerative disease of the central nervous system, and conventional treatments have limited efficacy or side effects. Ghrelin, a 28-amino acid octanoylated peptide, has been reported to have neuroprotective effects, including anti-oxidation, anti-inflammation, and a...

journal_title：Frontiers in pharmacology

authors： Liu F,Li Z,He X,Yu H,Feng J

更新日期：2019-11-06 00:00:00

abstract：:Trepibutone was widely used for cholelithiasis, cholecystitis, biliary tract dyskinesia, cholecystectomy syndrome, and chronic pancreatitis in clinic. However, few investigations on trepibutone have been conducted. In this study, an accurate, sensitive, and selective analytical method was developed and successfully ap...

journal_title：Frontiers in pharmacology

authors： Sun Z,Yang J,Liu L,Xu Y,Zhou L,Jia Q,Shi Y,Du X,Kang J,Zuo L

更新日期：2019-11-04 00:00:00

abstract：:Actinidia chinensis Planch. (A. chinensis), commonly known as Chinese kiwifruit, is a China native fruit, which becomes increasingly popular due to attractive economic, nutritional, and health benefits properties. The whole plant including fruits, leaves, vines, and roots of A. chinensis are used mainly as food or add...

journal_title：Frontiers in pharmacology

authors： He X,Fang J,Chen X,Zhao Z,Li Y,Meng Y,Huang L

更新日期：2019-10-30 00:00:00

abstract：:Limited data are available on the adherence to opioid therapy and the influence of different patient groups on adherence. This study examined the patterns of adherence in opioid naïve and opioid existing patients with varying age and gender. This retrospective cohort study was conducted using the prescription database...

journal_title：Frontiers in pharmacology

authors： Zin CS,Taufek NH,Ahmad MM

更新日期：2019-10-29 00:00:00

abstract：:The clinical practice of selective serotonin reuptake inhibitor (SSRI) augmentation relies heavily on trial-and-error. Unfortunately, the drug combinations prescribed today fail to provide relief for many depressed patients. In order to identify potentially more effective treatments, we developed a computational model...

journal_title：Frontiers in pharmacology

authors： Camacho MB,Vijitbenjaronk WD,Anastasio TJ

更新日期：2019-10-25 00:00:00

abstract：:Flavonoids are some of the most important natural products with a variety of physiological activities. 8-Formylophiopogonanone B (8-FOB) is a naturally existing homoisoflavonoid in Ophiopogon japonicus. Paraquat (PQ) has been widely used as a potent herbicide and has high toxicity in humans. The goal of the present st...

journal_title：Frontiers in pharmacology

authors： Qian JY,Deng P,Liang YD,Pang L,Wu LC,Yang LL,Zhou Z,Yu ZP

更新日期：2019-10-24 00:00:00

abstract：:Benefiting from the continuously clarifying underlying biology of immune checkpoints and ligand-receptor interactions, the emergence of new anticancer treatment strategy, immunotherapy has shown substantial benefits on several liquid and solid tumors. Immune checkpoint inhibitors (ICIs) can block the negative regulato...

journal_title：Frontiers in pharmacology

authors： Wang H,Mustafa A,Liu S,Liu J,Lv D,Yang H,Zou J

更新日期：2019-10-23 00:00:00

abstract：:Melanoma immunotherapy, specifically the autotransplant of dendritic cells charged with tumors antigens, has shown promising results in clinical trials. The positive clinical effects of this therapy have been associated to increased Th17 response and delayed-type hypersensitivity (DTH) against to tumor antigens. Some ...

journal_title：Frontiers in pharmacology

authors： Robles-Planells C,Michelson SA,Mena J,Escrig D,Rojas JL,Sanchez-Guerrero G,Hernández R,Barrera-Avalos C,Rojo LE,Sauma D,Kalergis AM,Imarai M,Fernández R,Robles CA,Leiva-Salcedo E,Santander R,Escobar A,Acuña-Castillo C

更新日期：2019-10-22 00:00:00

abstract：:Although the oral route is the most convenient route for drug administration, there are a number of circumstances where this is not possible from either a clinical or pharmaceutical perspective. In these cases, the rectal route may represent a practical alternative and can be used to administer drugs for both local an...

journal_title：Frontiers in pharmacology

authors： Hua S

更新日期：2019-10-16 00:00:00

abstract：:Obesity is constantly rising into a major health threat worldwide. Activation of brown-like transdifferentiation of white adipocytes (browning) has been proposed as a promising molecular target for obesity treatment. In this study, we investigated the effect of ginsenoside Rb1 (Rb1), a saponin derived from Panax ginse...

journal_title：Frontiers in pharmacology

authors： Lim S,Park J,Um JY

更新日期：2019-10-15 00:00:00

abstract：:In angiotensin II (Ang II)-dependent hypertensive rats there is an increased expression of proximal tubule angiotensinogen (AGT), collecting duct renin and angiotensin converting enzyme (ACE), which contributes to intratubular Ang II formation. Ang II acts on Ang II type 1 receptors promoting sodium retention and vaso...

journal_title：Frontiers in pharmacology

authors： Gonzalez AA,Gallardo M,Cespedes C,Vio CP

更新日期：2019-10-15 00:00:00

abstract：:Arsenic is a toxic environmental contaminant. Long-term exposure to arsenic through drinking water induces human cancers. However, it is as yet uncertain about the mechanisms of arsenic induced carcinogenesis. Although the effects of low-dose arsenicals on proliferation and cell cycle have been revealed by short time ...

journal_title：Frontiers in pharmacology

authors： Chen Y,Liu X,Wang H,Liu S,Hu N,Li X

更新日期：2019-10-11 00:00:00

abstract：:Background: Shexiang Baoxin Pill (SBP) is a well-known composite formula of traditional Chinese medicine (TCM), which is commonly used today in treating cardiovascular diseases. SBP consists of seven materials thereof, including Moschus, extract of Ginseng Radix et Rhizoma, Bovis Calculus Artifactus, Cinnamomi Cortex,...

journal_title：Frontiers in pharmacology

authors： Xu ML,Zheng ZY,Xia YJ,Liu EY,Chan SK,Hu WH,Duan R,Dong TT,Zhan CS,Shang XH,Tsim KW

更新日期：2019-10-09 00:00:00

abstract：:There is a growing interest in the pharmaceutical industry to design novel tailored drugs for RNA targeting. The vertebrate-specific RNase A superfamily is nowadays one of the best characterized family of enzymes and comprises proteins involved in host defense with specific cytotoxic and immune-modulatory properties. ...

journal_title：Frontiers in pharmacology

authors： Prats-Ejarque G,Lu L,Salazar VA,Moussaoui M,Boix E

更新日期：2019-10-09 00:00:00

abstract：:Nanoparticle-based antibiotic constructs have become a popular area of investigation in the biomedical sciences. Much of this work has pertained to human diseases, largely in the cancer therapy arena. However, considerable research has also been devoted to the nanochemistry for controlling infectious diseases. Among t...

journal_title：Frontiers in pharmacology

authors： Labruère R,Sona AJ,Turos E

更新日期：2019-10-04 00:00:00

abstract：:l-3,4-Dihydroxyphenylalanine (l-DOPA) is the most effective therapeutic agent for Parkinson's disease (PD). l-DOPA is traditionally believed to be an inert amino acid that exerts actions and effectiveness in PD through its conversion to dopamine. In contrast to this generally accepted idea, l-DOPA is proposed to be a ...

journal_title：Frontiers in pharmacology

authors： Goshima Y,Masukawa D,Kasahara Y,Hashimoto T,Aladeokin AC

更新日期：2019-10-03 00:00:00

abstract：:Cannabinoids exhibit anti-inflammatory and antitumorigenic properties. Contrary to most cannabinoids present in the Cannabis plant, some, such as O-1602 and abnormal cannabidiol, have no or only little affinity to the CB1 or CB2 cannabinoid receptors and instead exert their effects through other receptors. Here, we in...

journal_title：Frontiers in pharmacology

authors： Tomko A,O'Leary L,Trask H,Achenbach JC,Hall SR,Goralski KB,Ellis LD,Dupré DJ

更新日期：2019-09-27 00:00:00

abstract：:Uterine leiomyomas are the most common benign neoplasms in women of reproductive age. However, non-surgical treatments for uterine myomas have not been fully evaluated. In Korea and China, Gyejibongnyeong-hwan (GBH) is widely used to treat gynecological diseases. Thus, we investigated the effects of GBH in human uteri...

journal_title：Frontiers in pharmacology

authors： Lee SM,Choi ES,Ha E,Ji KY,Shin SJ,Jung J

更新日期：2019-09-25 00:00:00

abstract：:Purpose: Gender differences exist in the prevalence of asthma and allergic diseases, partially due to the effects of sex hormones on the development of allergic manifestations. Women, compared with men, are more prone to suffer allergic asthma, experience difficulties in controlling asthma symptoms, and show adverse r...

journal_title：Frontiers in pharmacology

authors： Esposito R,Spaziano G,Giannattasio D,Ferrigno F,Liparulo A,Rossi A,Roviezzo F,Sessa M,Falciani M,Berrino L,Polverino M,Polverino F,D'Agostino B

更新日期：2019-09-24 00:00:00

abstract：:Gamithromycin is approved for the treatment and prevention of bovine respiratory disease (BRD), which is caused mainly by Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma species. In this study, multiple dosage regimens were administered to the neutropenic mouse lung infection model in ...

journal_title：Frontiers in pharmacology

authors： Yang Q,Liu X,Zhang C,Yong K,Clifton AC,Ding H,Liu Y

更新日期：2019-09-24 00:00:00

abstract：:Health technology assessment (HTA) is the systematic evaluation of the properties and impacts of health technologies and interventions. In this article, we presented a discussion of HTA and its evolution in Brazil, as well as a description of secondary data sources available in Brazil with potential applications to ge...

journal_title：Frontiers in pharmacology

authors： Ali MS,Ichihara MY,Lopes LC,Barbosa GCG,Pita R,Carreiro RP,Dos Santos DB,Ramos D,Bispo N,Raynal F,Canuto V,de Araujo Almeida B,Fiaccone RL,Barreto ME,Smeeth L,Barreto ML

更新日期：2019-09-23 00:00:00

abstract：:Calcium-activated K+ channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated homology models of the C-terminal calmodulin-binding domain (CaM-BD) of ...

journal_title：Frontiers in pharmacology

authors： Shim H,Brown BM,Singh L,Singh V,Fettinger JC,Yarov-Yarovoy V,Wulff H

更新日期：2019-09-20 00:00:00

abstract：:Neonatal epileptic encephalopathy (NEE), as a result of pyridoxine 5'-phosphate oxidase (PNPO) deficiency, is a rare neural disorder characterized by intractable seizures and usually leads to early infant death. The clinical phenotypes do not respond to antiepileptic drugs but are alleviated in most cases by giving la...

journal_title：Frontiers in pharmacology

authors： Chen PY,Tu HC,Schirch V,Safo MK,Fu TF

更新日期：2019-09-20 00:00:00

abstract：:Persistent activation of STAT3 plays an important role in the development of triple-negative breast cancer (TNBC), and suppression of STAT3 is considered as a novel approach for cancer therapy. In this project, we aimed to examine the anticancer activity and molecular mechanism of eupalinolide J (EJ) in TNBC cells. Th...

journal_title：Frontiers in pharmacology

authors： Lou C,Chen Y,Zhang J,Yang B,Zhao H

更新日期：2019-09-19 00:00:00

abstract：:Deregulated activity of the Src tyrosine kinases leads to malignant transformation. Since the FDA approval of the tyrosine kinase inhibitor, imatinib, in 2001 for the treatment of chronic myeloid leukemia (CML), the number of these inhibitors together with Src tyrosine kinase inhibitors (STKIs) has increased notably d...

journal_title：Frontiers in pharmacology

authors： Rivera-Torres J,San José E

更新日期：2019-09-18 00:00:00

abstract：:The diagnosis and management of pain is an everyday occurrence in dentistry, and its effective control is essential to ensure the wellbeing of patients. Most tooth-associated pain originates from the dental pulp, a highly vascularized and innervated tissue, which is encased within mineralized dentin. It plays a crucia...

journal_title：Frontiers in pharmacology

authors： Schuh CMAP,Benso B,Aguayo S

更新日期：2019-09-18 00:00:00

abstract：:Antipsychotic drugs are often used for the treatment of behavioral and psychological symptoms of dementia (BPSD), especially psychosis and behavioral disturbances (e.g., aggression and agitation). They are prescribed alone or in conjunction with anti-dementia (e.g., anti-Alzheimer's disease drugs) and other psychotrop...

journal_title：Frontiers in pharmacology

authors： Ohno Y,Kunisawa N,Shimizu S

更新日期：2019-09-17 00:00:00

abstract：:Panax ginseng C.A. Meyer (Araliaceae), a popular tonic and dietetic herbal medicine, has been traditionally prescribed in China and other countries to treat affective disorders. The medicinal parts of ginseng, the roots and flower buds, have become increasingly popular as dietary supplements due to the current holisti...

journal_title：Frontiers in pharmacology

authors： Wang G,Lei C,Tian Y,Wang Y,Zhang L,Zhang R

更新日期：2019-09-13 00:00:00

abstract：:Random-pattern skin flap replantation is commonly used to repair skin defects during plastic and reconstructive surgery. However, flap necrosis due to ischemia and ischemia-reperfusion injury limits clinical applications. Betulinic acid, a plant-derived pentacyclic triterpene, may facilitate flap survival. In the pres...

journal_title：Frontiers in pharmacology

authors： Li J,Bao G,ALyafeai E,Ding J,Li S,Sheng S,Shen Z,Jia Z,Lin C,Zhang C,Lou Z,Xu H,Gao W,Zhou K

更新日期：2019-09-13 00:00:00

abstract：:We report on a patient who developed acute liver failure while being treated with metamizole. After liver transplantation, the patient recovered rapidly. Liver biopsy showed massive necrosis and lobular infiltration of lymphocytes. A lymphocyte transformation test performed 20 months after transplantation was positive...

journal_title：Frontiers in pharmacology

authors： Krisai P,Rudin D,Grünig D,Scherer K,Pichler W,Terracciano L,Krähenbühl S

更新日期：2019-09-11 00:00:00

abstract：:Over the last decade, several studies demonstrated that prenylation of flavonoids enhances various biological activities as compared to the respective nonprenylated compounds. In line with this, the natural prenylated isoflavonoid alpinumisoflavone (AIF) has been explored for a number of biological and pharmacological...

journal_title：Frontiers in pharmacology

authors： Ateba SB,Mvondo MA,Djiogue S,Zingué S,Krenn L,Njamen D

更新日期：2019-09-10 00:00:00

abstract：:Background: Formal definitions allow selecting terms (e.g., identifying all terms related to "Infectious disease" using the query "has causative agent organism") and terminological reasoning (e.g., "hepatitis B" is a "hepatitis" and is an "infectious disease"). However, the standard international terminology Medical D...

journal_title：Frontiers in pharmacology

authors： Bousquet C,Souvignet J,Sadou É,Jaulent MC,Declerck G

更新日期：2019-09-10 00:00:00

abstract：:Anatomical Therapeutic Chemical (ATC) classification system proposed by the World Health Organization is a widely accepted drug classification scheme in both academic and industrial realm. It is a multilabeling system which categorizes drugs into multiple classes according to their therapeutic, pharmacological, and ch...

journal_title：Frontiers in pharmacology

authors： Wang X,Wang Y,Xu Z,Xiong Y,Wei DQ

更新日期：2019-09-05 00:00:00

abstract：:To provide better therapeutic avenues for treating tongue squamous cell carcinoma (TSCC), a series of experiments about the effects of microRNA (miR)-532-3p on TSCC malignant behaviors were carried out. The result showed that miR-532-3p was down-regulated and C-C chemokine receptor 7 (CCR7) was up-regulated in the tum...

journal_title：Frontiers in pharmacology

authors： Feng C,So HI,Yin S,Su X,Xu Q,Wang S,Duan W,Zhang E,Sun C,Xu Z

更新日期：2019-08-29 00:00:00

abstract：:Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that affects mostly the elderly population. At the moment, no effective treatments are available in the market, making the whole situation a compelling challenge for societies worldwide. Recently, novel mechanisms have been proposed to ...

journal_title：Frontiers in pharmacology

authors： Cenini G,Voos W

更新日期：2019-08-23 00:00:00

abstract：:Scoring functions play an important role in structure-based virtual screening. It has been widely accepted that target-specific scoring functions (TSSFs) may achieve better performance compared with universal scoring functions in actual drug research and development processes. A method that can effectively construct T...

journal_title：Frontiers in pharmacology

authors： Wang D,Cui C,Ding X,Xiong Z,Zheng M,Luo X,Jiang H,Chen K

更新日期：2019-08-22 00:00:00

abstract：:Background: Rheumatoid arthritis is a type of systemic and complex autoimmune other disease characterized by chronic joint inflammation. Spleen tyrosine kinase (Syk) inhibitors are regarded as an effective alternative to existing drugs for the treatment of this disease. However, studies evaluating fostamatinib, a new ...

journal_title：Frontiers in pharmacology

authors： Kang Y,Jiang X,Qin D,Wang L,Yang J,Wu A,Huang F,Ye Y,Wu J

更新日期：2019-08-14 00:00:00

abstract：:Objective: Calcium dobesilate (CaD), an effective drug for the treatment of diabetic microvascular complications, especially diabetic retinopathy, is widely used in the clinic. Interestingly, several studies have indicated that CaD is therapeutic for diabetic kidney disease (DKD). Recently, evidence has indicated that...

journal_title：Frontiers in pharmacology

authors： Wang Y,Lu YH,Tang C,Xue M,Li XY,Chang YP,Cheng Y,Li T,Yu XC,Sun B,Li CJ,Chen LM

更新日期：2019-08-09 00:00:00

abstract：:Over the past several decades, natural products with poly-pharmacological profiles have demonstrated promise as novel therapeutics for various complex diseases, including cancer. Berberine (PubChem CID: 2353), a soliloquies quaternary alkaloid, has been validated to exert powerful effects in many cancers. However, the...

journal_title：Frontiers in pharmacology

authors： Guo P,Cai C,Wu X,Fan X,Huang W,Zhou J,Wu Q,Huang Y,Zhao W,Zhang F,Wang Q,Zhang Y,Fang J

更新日期：2019-08-06 00:00:00

abstract：:Background and Purpose: Septic cardiomyopathy, which is one of the features of multi-organ dysfunction in sepsis, is characterized by ventricular dilatation, reduced ventricular contractility, and reduction in ejection fraction and, if severe, can lead to death. To date, there is no specific therapy that exists, and i...

journal_title：Frontiers in pharmacology

authors： Tan S,Long Z,Hou X,Lin Y,Xu J,You X,Wang T,Zhang Y

更新日期：2019-08-05 00:00:00